Is it possible to change what content is shown and how it is arranged for the Application Home Page?

Hello Matt,

currently you can change e.g. the content of the welcome text block at Administration -> system settings -> general.
There is also an enterprise feature that allows you to change i.e. the theme and logo. [1]

Furthermore, you might be interested in the current rework of the homepage together with the my page:
https://community.openproject.org/wp/52597

Best,

Alexander

[1] https://www.openproject.org/docs/system-admin-guide/design/#set-custom-color-theme-and-logo-enterprise-add-on